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Effects offenofibrate treatment on cardiovascular disease risk in 9,795 individuals with type 2diabetes and various components of the metabolic syndrome. The role of ATR in phosphory-lating S15 on p53 was shown in ?-irradiated broblasts that were transfected with avector expressing a catalytically inactive mutant of ATR, designated ATRki.Overexpression of ATRki abrogated UV-induced p53 S15 phosphorylation .Herein, it was shown that ATR phosphorylates p53 on S37 (also a phosphorylationsite for DNA-PK) in vitro. The ciliary dynein locatedin thearms oftheA microtubule forms temporary cross-bridgeswith the B microtubule of the adjacent doublet. If the tympanic membraneis freely mobile on insuflations of the ear, then otitis media is not present.
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